Monday, August 19, 2013

Is creativity an illness? But then... what is an illness?

 Is creativity an illness? But then... what is an illness?

Are you creative? Do you ever feel that when your creativity strikes you become absolutely compulsive about your "inspiration," and totally depressed when, for some reason, your inspiration wanes? It always strikes me to read about how some of the most beautiful works of art were created: their creators were obsessed, compulsive, borderline dysfunctional. Gabriel Garcia Marquez sold his car and had his family live on credit for eighteen months so he could write One hundred years of solitude. Brunelleschi's obsession was the dome of Santa Maria del Fiore, Antoni Gaudi's obsession was La Sagrada Familia. It seems to me that obsessions may ruin your life (or most likely the life of your closest ones) when you have them, but they may also lead to the most wonderful things.

So, is creativity a good thing or is it an illness?

My friend and collaborator Tanmoy Bhattacharya brought to my attention an interesting BBC post that discussed the issue. The article came up in a Facebook discussion because it raised the question: "How do you define illness? When, exactly, does a behavior trespass the normality threshold and becomes an illness?" I really liked Tanmoy's take on the issue, and I asked him permission to repost it here on the blog. It's the best thing I could get since he won't do a guest blog for me. :-)

I think he raises excellent points on the complexity of the brain, its stimuli as well as its constraints. I enjoyed reading it, I hope you will too. And if after reading this you have questions for Tanmoy, go ahead and post them in the comments and I will forward them to him.

TB: In a system as complex as the brain, which interacts with such diverse environments, it is difficult to define health and disease. There has been a long standing hypothesis that certain brain functions like deductive logic and creativity are kept in check evolutionarily because the same "structure" that can give rise to very highly creative adaptations in one environment would give rise to maladaptive behavior in a different environment. The interest in the research is, therefore, understanding the architectural limits on the brain, not to stigmatize writers or expect every bipolar to pen out a story about an old man and the sea.

EEG: That's a very interesting theory. All greatest masterpieces required such great energy and dedication from their creators that these individuals had to, at some level, become unsociable, as focused as they were on their creation. I can see how, at a species level, "being socially fit" puts a constraint on the amount of time and "obsession" the brain can dedicate to a certain task.

TB: I do not believe that we yet have a definition of illness which is "biologically" meaningful. Sure, there is a diagnostic manual that tells a doctor today when to diagnose a particular mental illness, but it is more an expression of "social" reality than a "biological" reality. So, for example, the discussion of whether homosexuality is a disease is not argued on any grounds about what it does or does not do to the person, but rather whether the majority of doctors consider it within the "normal" spectrum of behavior. No wonder its classification changed from a disease to a non-disease as the social acceptability of homosexuality grew: not because such acceptance lessened the mental load on the person with the trait (it is now not considered a disease even when the person with the trait lives in a non-accepting community), but because it became "socially" acceptable as a "normal" behavior. Currently, there is a similar debate about whether bereavement distress should be considered normal even when it leads to behavior sufficiently aberrant to otherwise merit a diagnosis of clinical depression. In other words, the question is not whether the person is depressed after a loss: the question is whether it is a disease (possibly temporary like say getting the 'flu is a disease) or whether it is not a disease because it is "normal". The classification is not done based on any kind of biological reality, except whether it is considered normal; which is determined by methods of social science, not biology.

Does this concept of normality depend on a biological reality? In other words, is there a way, other than surveying doctors (the social science method), to figure out whether some one is abnormal? Remember that we know pretty much that all of us are different in many ways, if you defined me abnormal simply because I am unique (which I certainly am), then everyone would be abnormal. One could always say that one should not look at the totality (which made everyone unique), but trait by trait, and ask whether I have traits that very few other people have? Defining abnormality this way would, of course, make Picasso abnormal; but during a mass hysteria, it would classify everyone as normal. We again see that this definition fails to capture the abnormality that is relevant to defining disease.

I claim that the only way people have found to capture the relevant abnormality is by taking the design stance: human brains (and bodies) are supposed to be "for" something. When the organ (or the totality) is carrying out this function, it is normal; when it fails to carry out this function, it is abnormal. Note that this does not solve the underlying problem: someone still has to define the function, but that turns out to be an easier problem.

We could define a disease objectively as a malfunction if we could define function objectively. And, here, biology can bring an insight: the function of brains (and bodies) is to survive and use the environment, physical, biological, and social, to further the fundamental goals of long term survival of the traits. This is usually called reproduction, but it is far more subtle: for example, one can help raise grandchildren and contribute to the long term survival; under appropriate conditions, one can help other helpful members of one's community to help survival of the helpfulness trait. The mathematics is not simple, but recent work has made much of this clearer, and it is far more than pure reproduction. The part relevant to this discussion is that for a social animal this survival depends a lot on social calculations as well as other considerations.

So, then, we can define function as being able to properly calculate and take appropriate action; but that depends on the environment one faces. The same trait of fast decisive action to take the life of an unexpected person is wonderful in times of violent combat but completely malfunctional in a peaceful society. Similarly, it is easy to show that a mental make up that helps everyone, whether or not they are helpful to others, is malfunctional in the sense that it does not help its own survival except in societies that pays a high moral premium on that. Now, since most traits will find themselves in various environments, the malfunctional has to be defined as an intermediate: it should not be "fatal" in any of the environments that an individual is likely to face. But, this depends on the environments one is "likely" to face.

Given this situation, therefore, most traits tune themselves to intermediate values, because extreme values are typically extremely ill suited in some environments one is likely to face. And, all this is further constrained by the possible organization of the brain: for example, it is completely possible that the brain is composed of two parts, one that can analyze and model its environment in terms of an "open-loop" system controlled by impersonal physical laws which constrain and guide change, and a social system that can alternately assign agency (or "will") to parts of the environment. If this simple separation of thought patterns is an useful approximation, the division of resources between the two will affect a lot of behavior: a lot of resources devoted to the physical system will make one unable to understand complicated social dynamics; whereas too high a reliance on the social system might make one unable to understand that physical phenomenon often do not have wills and desires. Both of these taken to an extreme are obviously malfunctional, and, therefore, diseased: one can think of autism or schizophrenia as examples illustrating such symptoms. But, where exactly one stops being analytical and starts being high-functional autistic will depend on what environment one is defining with respect to: when the norm is highly complex social environments, one will probably classify some highly analytic people as diseased because they cannot function in society (i.e., the "mad scientist" or "computer geeks" will get classified as "mad" or "autistic"), whereas when complex physical systems but with little social structure are the norm, some people who see willful patterns in the universe will find themselves considered ill (e.g., a "religious fanatic" will be considered "mad").

So, what have we done through all this argument? We started by arguing that DSM (diagnostic manual) definitions depend on a certain standard of normal and are not objective. Through the chain of arguments, I have tried to establish that the former (i.e. dependence on the standard of normal) is inherent part of the problem, and cannot be removed except in the trivial sense that some things have never been normal. I have also argued, however, that this dependence does not need to be subjective: what is important is not what the "doctors" have experienced as normal, but rather the environments that the *person* being diagnosed has experienced and is likely to experience.

The interesting question is that supposing we take a bunch of brains and tune up their creativity (by changing whatever neurotransmitter chemistry or electrochemical connections that we need to). Now, in some environments and depending on the rest of the circuits in the brain, this will work perfectly fine and be very useful in understanding and modeling otherwise-hard-to-model systems (somewhat similar to a physical effect called "annealing"). If the same tuning is done to a different brain which does not have the same set of controls, this tuning could lead to a bipolar disorder. Basically this hypothesis would say that creativity needs to be balanced by other control systems, so any means of independent inheritance will quite often lead to getting the creativity structures without the control structures, leading to madness. Under this hypothesis, creative people are not insane, but biology would dictate that they are at a higher risk of having insane relatives (children/siblings/etc.) than less creative people.

But, there is a different possibility as well: the "control" unit hypothesized in the previous post may not be inherited much, but developed based on experiences; or its need may be dependent on the environment. In this case, the only difference between creative people and people with some forms of insanity would be the environments they have faced or will face. Creative people can then look at bipolars and paraphrase Bradford "But for the grace of environment, there go I". We do not know if either of these hypotheses are correct, but I hope I have explained why I find it interesting to ask these questions, and why the data presented in the article is consequently interesting.

Why You Should Eat Your Broccoli

 Why You Should Eat Your Broccoli



Many of us hate broccoli along with all vegetables. But, there is something different about this one along with its cruciferous kind, which includes cabbage, bok choy, and brussel sprouts. That is, it has been recently discovered that these vegetables contain a compound, sulforaphane (SFN) that has not one but two mechanisms in preventing cancer.

Historically it was believed that genetic abnormalities and mutations were the primary underlying cause for diseases. Now epigenetics has become a field of study that is recognized as having greater than or equal importance in discovering disease susceptibility. Epigenetics studies how diet, toxins and other forces can change the expression of genes without altering the DNA sequence.

Sulforaphane was found to have the ability to fight cancer despite a person’s DNA sequence. Studies have shown that it involves a mechanism called histone deacetylases or HDAC’s. This is a family of enzymes that interfere with the genes that suppress tumors. There are also HDAC inhibitors, which include the compound SFN, and these can undo this interference by restoring the essential balance in preventing cancer.
                                  

New studies by researchers in Linus Pauling institute at Oregon State University have discovered another epigenetic mechanism, DNA methylation (DNMT), which plays a similar role. These two mechanisms work together in maintaining proper cell function. As they are both influenced by sulforaphane, this compound can help to fix disruptions in these mechanisms. SFN is able to adjust the process of HDAC and DNMT so that they are in balance.

The effect of sulforaphane on DNA methylation was explored in a study published in the journal Clinical Epigenetics. It examined the methylation of the gene, cyclinD2, in prostate cancer cells. The results of the study gave insight into how SFN regulates gene expression. It demonstrated that it is an agent in preventing prostate cancer. The positive effect of SFN is not limited to prostate cancer but researchers say that the mechanisms are relevant in other types of cancers such as colon and breast cancer.

“It’s increasingly clear that sulforaphane is a real multi-tasker”, said Emily Ho, an associate professor at OSU College of Public Health and Human Sciences, “the more we find out about it, the more benefits it appears to have.” She believes that broccoli may be one of the strongest anti-cancer fighters known today.

Another study conducted at John’s Hopkins school of medicine found another health benefit of sulforaphane. It is able to kill helicobacter pylori, a bacterium that causes stomach ulcers and potentially deadly stomach cancers. It was even found to be able to kill types of helicobacter that is resistant to common antibiotics.
                             

It is certainly confirmed that broccoli is a super vegetable in having this cancer-preventing compound!

Sunday, July 14, 2013

RNA Virus

RNA Virus


During the process of DNA replication, errors occasionally occur in the polymerization of the second strand. These errors, called mutations, can have an impact on the phenotype of an organism, especially if they occur within the protein coding sequence of a gene. Error rates are usually very low 1 error in every 10–100 million bases—due to the "proofreading" ability of DNA polymerases.(Without proofreading error rates are a thousand-fold higher; because many viruses rely on DNA and RNA polymerases that lack proofreading ability, they experience higher mutation rates.) Processes that increase the rate of changes in DNA are called mutagenic: mutagenic chemicals promote errors in DNA replication, often by interfering with the structure of base-pairing, while UV radiation induces mutations by causing damage to the DNA structure.Chemical damage to DNA occurs naturally as well, and cells use DNA repair mechanisms to repair mismatches and breaks in DNA—nevertheless, the repair sometimes fails to return the DNA to its original sequence.

In organisms that use chromosomal crossover to exchange DNA and recombine genes, errors in alignment during meiosis can also cause mutations. Errors in crossover are especially likely when similar sequences cause partner chromosomes to adopt a mistaken alignment; this makes some regions in genomes more prone to mutating in this way. These errors create large structural changes in DNA sequence—duplications, inversions or deletions of entire regions, or the accidental exchanging of whole parts between different chromosomes (called translocation).

Treatment for Brain Tumour

Treatment for Brain Tumour



The treatment of human brain tumors rarely. By type and stage of cancer, patients can be treated with surgery, radiation therapy or chemotherapy. Some patients receiving combination therapy.

No version "at any stage of disease, patients may receive treatment to control pain and other symptoms of cancer, reduce the side effects of treatment, and any emotional problems. Thats kind of treatment is called symptom management, supportive care, or palliative treatment.

Doctor is the best person to describe treatment options and discuss the expected results.

Patient may want to talk about the doctors involved in clinical trials, it is a study, to learn a new way of treatment. The Department of "commitment to research Zell" for more information about clinical tryals.

Surgery is the most common treatment for brain tumors. Surgery to open the skull is known as kranyotomi. This is done under general anesthesia. Before the surgery began, the scalp shaved.Then the surgeon makes an pitche open and use a special kind of discovery, removal of a skull bone. Removal of some or all of the tumor, the surgeon James's opening in the skull bone plates or a metal or cloth. Surgeon and then close the incision in the scalp.
Radiotherapy

Radiation therapy (also known as radyotherapi) using high - high-energy rays to kill tumor cells.Radiation can be from X - rays, gamma rays, or protons. A huge machine Ames Radiation Oncology and organizations close to it. When it direkted of radiation in the brain or spinal cord.

Radiation therapy usually follows surgery. Of radiation to kill cancer cells can remain in place. In the past, patients did not have radiation therapy instead of surgery.

Patients in hospital or clinic for radiation therapy. The plan of treatment depends on the type and size of tumor and age of the patient. Each treatment lasted just minutes.

Doctor to make the step to protect surrounding healthy tissue tumors of the brain:

Fraktyonatyon - radyatyon usually to determine the treatment five days a week for several weeks. To provide a total dose of radiation over an extended time by half, to protect healthy tissue tumors in the region.

Hiperfraktyonatyon - Davis radiation small idol of patients two or three times a day, rather than a larger amount of time.

Stereotaktik radiotherapy - a narrow-beam radiation direkted lungs from different angles.Technique, patients wear the top of the strict structure. A wrong card or scan images to create the exact location of the tumor. Doctors use a computer to determine the necessary dose of radiation, as well as south and the angle of radiation beam. During the treatment, we can identify a single visit, or a few visits.

3 - Three-dimensional radiation therapy konformal - a computer creates a 3 - three-dimensional images, lungs and surrounding brain tissue. A type of medical purpose of the exact shape of the beam of radiation oncology. To accurately focus radiation beams defensive in normal brain tissue.

Proton beam radiation therapy - the source of the proton radiation, instead of X - ray. Dr. Ames proton beam cancer. Protons through healthy tissue without compromising it.
Tshemotherapi

Tshemotherapi, using drugs to kill cancer cells, is sometimes used to treat brain tumors. Drugs will decide either orally or through the injection. Either way, the drugs enter the blood circulation and the passage of the body. The drug is usually to return to the moon is as follows for each hour of treatment.

Tshemotherapi may determine the out-patient of the hospital, doctor's office or home. Rareli, patients may need to stay in hospital.

Children more likely than adults to chemotherapy. However, the elderly can have post-operative chemotherapy and radiotherapy.

For some patients with brain cancer, surgeons remove some chip implanted and tumors containing chemotherapy. Each woman is about the size of a dime. In the past few weeks, the chip is dissolved, the release of drugs to the brain. The drug can kill cancer cells.

Transgenic plants

Transgenic plants 

 

Transgenic plants plants created by introducing genes from other species through genetic engineering. These systems are usually developed to produce certain desirable characteristics such as resistance to disease, parasites and resistance to herbicides and resistance to certain environmental conditions. To know the transgenic plants and the risks and benefits, read on.
A transgenic organism is the term used to describe a type of genetically modified organism whose genetic material is manipulated to produce changes in the body with the leg you want. To achieve this objective, the genetic material or DNA of an organism is injected in the nucleus of cells play another agency in the same or different, in order to produce or transport suddenly desirable. This technique of creating transgenic organisms is called recombinant DNA. In other words, transgenic organisms are organisms with a single gene or genes transferred from another organism of the same or different species in the laboratory using the technology of recombinant DNA. This technique can be done in both plants and animals to create transgenic plants and animals.

Transgenic plants Appointment

Transgenic plants are plants that are created by introducing genetic material from a different species, using genetic engineering to produce plants with specific characteristics. The genes of different species can be introduced into a plant in several ways. In general, it is easier to produce transgenic plants compared with transgenic animals. In plants, there is no difference between somatic and germ cells and therefore the genes can be introduced into somatic cells and tissues to produce transgenic plants.

In the past, new plant varieties containing genes from two species generated through hybridization or cross. However, the breeding took place between two closely related species. However, modern biotechnology and genetic engineering, integration of genetic material not only connected but also of exotic species to create transgenic plants and genetically modified. Bt corn, Bt cotton and golden rice are just some of the most common examples of transgenic plants created in this way.

Pros and cons of transgenic plants

Production of transgenic plants and the introduction of foreign genetic material is extremely doubtful. A range of benefits and risks of production of these plants have been identified by scientific studies. One of the main advantages of transgenic plants and crops by the introduction of some parts as you want, resistance to diseases, pests and herbicides. This in turn can increase crop yields to meet rising demand for food. Another advantage is that with the help of genetic engineering, it is possible to produce plants that can tolerate adverse environmental conditions such as drought and cold. Even the floor laden with large quantities of salt can be made with the production of genetically modified crops that can grow in saline soils.

All these advantages will ultimately benefit the agricultural sector. With the growing concern about the environmental impacts of using large-scale insecticides and pesticides is very important to reduce the use of these substances. Transgenic plants resistant to pesticides may play an important role in reducing the use of these chemicals. Plant varieties resistant to herbicides can reduce the negative effects of herbicides and the development of transgenic plants resistant to insects can help reduce the total amount of pesticides used. This, in turn, can improve environmental quality. Besides this, some transgenic plants can produce higher levels of nutrients that can improve the nutritional quality of food.

Despite these advantages, the development of genetically modified or altered are widely criticized, particularly by the fact that these plants have a negative impact on the environment, ecosystem and biodiversity. Many also expressed concern that the genetic material of transgenic plants can be transferred to non-GM plant varieties. Although herbicide-resistant transgenic plants, the same quality, if transferred to weeds can make it very difficult to control weeds. Apart from these, it was found that some genetically modified foods, developed by the animals to cause allergic reactions in some individuals. However, no incidence of these severe allergies have been reported in case of manufacture of food for human consumption.

Another issue raised by critics of GM crops is that these plants can release genes of antibiotic resistance in soil, which can cause soil micro-organisms resistant to antibiotics. Apart from these, laboratory studies have suggested that the introduction of genetically modified crops may affect other organisms. How, for example, Bt corn pollen can affect the larvae of monarch butterflies and moths, if they feed on the leaves of the plant milkweed, covered with pollen from maize Bt, but the supporters of GM and GM crops have refuted the claim this and claims that Bt corn pollen on milkweed leaves can reach a high level of concentration to produce such effects. Learn more about

* The investigation of DNA
* Genetically Modified Foods: Benefits and Risks

Briefly, transgenic plants, risks to human health and ecosystems is a controversial issue. Therefore, further detailed studies and investigations to resolve disputes related to transgenic plants, so that consumers can discover the truth about these plants and genetically modified foods. Apart from these, there are many ethical issues are also associated with transgenesis, which must also be adequately addressed.